Ways to escape catch-22

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Ways to escape catch-22

To attract investors, smaller drugs developers need to show that they have products close to regulatory approval. But to reach that stage requires vast investments of high-risk capital. There are no easy ways to plug the gap but alliances with big pharma and forward sales of royalties can help. Mark Brown reports.

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THE WORLD'S DOCTORS write more than 1,100 prescriptions for GlaxoSmithKline medicines every minute. The company made pre-tax profits of £6.7 billion ($11 billion) last year. Making people better is big business.

UK pharmaceuticals group GSK's products treat asthma, depression, diabetes, migraine, nicotine addiction and a host of other ailments. But GSK hasn't always been so multi-faceted. Long before its merger with SmithKline Beecham, Glaxo Wellcome's growth was largely driven by the success of a single product, Zantac, which soothes ulcers, indigestion and heartburn.

"That's the beauty of this industry," says Chris Collins, chief executive of life science and medical technology specialist Code Securities. "You can suddenly develop a blockbuster that sells in billions every year and is protected by patents for 10 or 12 years."

Because blockbuster drugs that generate over $1 billion a year can transform a company, global pharmaceuticals companies like GSK ? big pharma ? invest heavily in research and development. GSK spent £2.7 billion on R&D in 2002.

But internal R&D programmes are not providing enough blockbusters. So big pharma is turning to smaller companies specializing in biotechnology that, in Europe at least, are often short of cash.

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